|A systematic review and meta-analysis of the composition of the lung microbiome in lung cancer|
Background: Although recent research has linked an imbalance in the composition of the respiratory microbiome to a variety of chronic respiratory diseases, the relationship between the lung microbiome and lung cancer has received little attention. Individual study reports on respiratory microbiome alterations in lung cancer complicate determining how the lung microbiome is linked to lung cancer. As a result, for the first time, we combine publicly available 16S rRNA gene sequence data on lung tissue samples from lung cancer patients to identify bacterial taxa that differ consistently between case and control groups.
Results: The current study’s findings indicate that the relative abundance of several bacterial taxa, including the Actinobacteria phylum, the Corynebacteriaceae and Halomonadaceae families, and the genera Corynebacterium, Lachnoanaerobaculum, and Halomonas, is significantly lower (p 0.05) in lung tumor tissues of lung cancer patients compared to tumor-adjacent normal tissues.
Conclusions: Despite the need to further investigate the findings, the current study lays the groundwork for future research and adds to our limited understanding of the lung microbiome’s key role and its complex interaction with lung cancer. More data on demographic factors and tumor tissue types would aid in characterizing the lung microbial community in accordance with disease subtypes and stages, as well as fully capturing the changes of the lung microbiome in lung cancer.